TIRAP Rabbit Polyclonal Antibody
CAT#: TA350510
Rabbit Polyclonal Anti-TIRAP Antibody
Size: 25 ul
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CNY 1,999.00
CNY 3,280.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 3,080.00
Specifications
Product Data | |
Applications | IHC |
Recommend Dilution | IHC: 25-100 Positive control: Human liver cancer Predicted cell location: Cytoplasm |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Full length fusion protein |
Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | toll-interleukin 1 receptor (TIR) domain containing adaptor protein |
Database Link | |
Background | The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. |
Synonyms | BACTS1; Mal; MyD88-2; wyatt |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Toll-like receptor signaling pathway |
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