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HMG1 (HMGB1) Rabbit Polyclonal Antibody
CAT＃: TA350691S
Rabbit Polyclonal Anti-HMGB1 Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
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CNY 6,650.00
Specifications
| Product Data | |
| Applications | IHC, WB |
| Recommend Dilution | WB: 500-2000 WB positive control: Human hepatocellsular carcinoma tissue, Hela and Jurkat cells, 293T cells and human breast infiltrative duct tissue IHC: 50-200 Positive control: Human thyroid cancer Predicted cell location: Nucleus |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human HMGB1 |
| Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 25 kDa |
| Gene Name | high mobility group box 1 |
| Database Link | |
| Background | High mobility group (HMG) proteins 1 and 2 are ubiquitous non-histone components of chromatin. Evidence suggests that the binding of HMG proteins to DNA induces alterations in the DNA architecture including DNA bending and unwinding of the helix. HMG proteins synergize with Oct-2, members of the NF˚B family, ATF-2 and c-Jun to activate transcription. Other studies indicate that phosphorylation of HMG protein is required to stimulate the transcriptional activity of the protein. Human HMG-1 and HMG-2 both contain two DNA-binding domains, termed HMG boxes. HMG proteins bind single-stranded DNA but induce conformational changes in double-stranded DNA alone. |
| Synonyms | HMG1; HMG3; SBP-1 |
| Reference Data | |
| Protein Families | Druggable Genome, Stem cell - Pluripotency, Transcription Factors |
| Protein Pathways | Base excision repair |
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