Interferon gamma (IFNG) Mouse Monoclonal Antibody [Clone ID: MD-2]

Specifications

Product Data
Clone Name	MD-2
Recommend Dilution	ELISA, Immunohistochemistry, Western Blot
Reactivity	Human, Rhesus Macaque
Host	Mouse
Clonality	Monoclonal
Immunogen	IFN-gamma
Formulation	Prior to lyophilization: 0.5 ml PBS + 125 mM trehalose.
Concentration	lot specific
Purification	Ion exchange chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	16.7 kDa
Gene Name	interferon, gamma
Database Link	NP_000610 Entrez Gene 3458 Human UniProt ID P01579
Background	The monoclonal antibody to human IFN-? (clone MD-2) was first described in 1985. It has shown to binds with high affinity to both natural and recombinant human IFN-? but does not neutralize the antiviral bioactivity of IFN-? in vitro. In a Western Blot the antibody reacts with the 20 kDa and 25 kDa polypeptides present in natural human IFN-? (van der Meide P.H. et al. 1985). The MD-2 antibody has been descriped as useful in a sandwich ELISA (van Dissel J.T. et al. 2011, Wassenaar A. et al. 1995 and Wierenga E.A. et al. 1990). Further, the antibody has proven to cross react with rhesus macaque, cynomolgus monkey and marmoset IFN-? and can be used for immunohistochemical staining of frozen tissues (Kap Y. et al. 2009).
Synonyms	IFG; IFI
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Allograft rejection, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Proteasome, Regulation of autophagy, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, Type I diabetes mellitus

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