CD247 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to the N-terminus of human CD3 zeta. This sequence is identical among human, rat and mouse species.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	~20 kDa
Gene Name	CD247 molecule
Database Link	NP_000725 Entrez Gene 12503 MouseEntrez Gene 25300 RatEntrez Gene 919 Human UniProt ID P20963
Background	CD3 is a glycoprotein consisting of up to five polypeptide chains (gp20, gp26, p16, p20, p28). It forms three dimmers: a heterodimer of gamma and epsilon chain, a heterodimer of delta and epsilon chains and a homodimer of two zeta chains or a heterodimer of zeta and eta chains. CD3 is required for proper assembly, trafficking and surface expression of TCR complex. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells. CD3 is involved in T cell activation, proliferation and apoptosis pathway. This protein is present on virtually all peripheral blood T cells and thymocytes. The CD3 zeta plays an important role in coupling antigen recognition to several intracellular signal transduction pathway. Low expression of the antigen results in impaired immune response.
Synonyms	CD3-ZETA; CD3H; CD3Q; CD3Z; IMD25; T3Z; TCRZ
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway

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