GSK3 alpha (GSK3A) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide surrounding to the epitope -RTSSFA- with a phosphorylation site at Ser21 of human GSK3-alpha protein. This sequence is identical among human, mouse and rat.
Formulation	This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	52 kDa
Gene Name	glycogen synthase kinase 3 alpha
Database Link	NP_063937 Entrez Gene 50686 RatEntrez Gene 606496 MouseEntrez Gene 2931 Human UniProt ID P49840
Background	Glycogen Synthase Kinase-3 has two isoforms, GSK-3a and GSK3β. GSK3 is a serine/threonine kinase that affects glycogen metabolism by phosphorylating and down-regulating the activity of muscle glycogen synthase as well as the regulation in Wnt signal pathway. GSK-3 alpha reduces the substrates beta-catenin and tau to imply an important role in Wnt signaling and tauopathies such as Alzheimer’s disease..
Synonyms	DKFZp686D0638
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Chemokine signaling pathway

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