Ezrin (EZR) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to the C-term portion of human Ezrin protein. This sequence is identical to human, rat, mouse, dog, Monkey, zebra fish, and human origins.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	~81 kDa
Gene Name	ezrin
Database Link	NP_001104547 Entrez Gene 22350 MouseEntrez Gene 54319 RatEntrez Gene 7430 Human UniProt ID P15311
Background	Villin 2, also known as Ezrin, p81, 80K, or cytovillin, is a cytoplasmic peripheral membrane protein which is enriched in microvilli and other cell surface structures. Villin belongs to a member of the gelsolin family of calcium-regulated actin-binding proteins. Unlike the ubiquitously expressed gelsolin, villin expression is restricted to simple epithelia of the gastrointestinal and urogenital tracts. It is localized to the apical cytoplasm and brush borders of these cells. Villin functions in the regulation of actin dynamics in the apical epithelium, capping, nucleating and/or severing actin filaments in a calcium-dependent manner and regulating cell shape in response to external stimuli. Villin serves as a tyrosine kinase substrate, and is phosphorylated in EGF-stimulated cells. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers.
Synonyms	CVIL; CVL; HEL-S-105; VIL2
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.