LCK Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide derived from Carboxyl-terminus of p56lck protein from human, rat, bovine, dog origin.
Formulation	This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	56 kDa
Gene Name	LCK proto-oncogene, Src family tyrosine kinase
Database Link	NP_001036236 Entrez Gene 16818 MouseEntrez Gene 313050 RatEntrez Gene 3932 Human UniProt ID P06239
Background	Lymphocyte specific protein tyrosine kinase (LCK) belongs to Src family protein-tyrosine kinase. It is essential for T-cell development and function. The activity p56lck is regulated by phosphorylation and dephosphorylation of two critical tyrosine residues Tyr394 and Tyr505. Tyr394 and Tyr505 are autophosphorylated after p56lck activation, whereas phosphorylation of Tyr505 is believed to be due to p50csk which negatively modulates P56lck activity. Autophosphorylation at Tyr505 of P56lck may represent an accessory mechanism for the down-regulation of the tyrosine kinase activity of P56lck.
Synonyms	IMD22; LSK; p56lck; pp58lck; YT16
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Stem cell - Pluripotency
Protein Pathways	Natural killer cell mediated cytotoxicity, Primary immunodeficiency, T cell receptor signaling pathway

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