CDK9 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to the C-terminus of human CDK9 protein. This sequence is identical to human, rat and mouse.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	~22 kDa
Gene Name	cyclin-dependent kinase 9
Database Link	NP_001252 Entrez Gene 1025 Human UniProt ID P50750
Background	CDK9 belongs to a member of the cyclin-dependent protein kinase (CDK) family. It is also known as an important cell cycle regulator. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. The CDK9 C-terminal tail sequence is important for the catalytic mechanism and imposes an ordered binding of substrates and release of products. It is regulated by the phosphorylation of CDK9 at Thr 29, Thr186.
Synonyms	C-2k; CDC2L4; CTK1; PITALRE; TAK
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Transcription Factors

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