FOXP3 Rabbit Polyclonal Antibody
CAT#: TA354703
Rabbit anti FOXP3 Polyclonal Antibody
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CNY 4,323.00
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Specifications
Product Data | |
Recommend Dilution | WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml |
Reactivity | Human, Rat, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | A synthetic peptide corresponding to the C-terminus of human FOXP3 protein. This sequence is identical within human, mouse, rat origins. |
Formulation | This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer. |
Purification | The Rabbit IgG is purified by Epitope Affinity Purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 52 kDa |
Gene Name | forkhead box P3 |
Database Link | |
Background | Forkhead/winged-helix box (Fox) genes are the transcriptional regulators and highly conserved across mammals. It contains a FOX DNA-binding domain and large polyglutamine tract. The FOXPs are involved in organogenesis and cell differentiation. FOXP3 is essential for normal immune homeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, at low level in CD4 positive/CD25 negative cells, and is absent in CD4 negative/CD8 positive T cells. FOXP3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells. |
Synonyms | AIID; DIETER; IPEX; JM2; PIDX; XPID |
Reference Data | |
Protein Families | Transcription Factors |
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