LRRK2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to C-terminus of human LRRK2.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	285 kDa
Gene Name	leucine-rich repeat kinase 2
Database Link	NP_940980 Entrez Gene 120892 Human UniProt ID Q5S007
Background	The leucine-rich repeat kinase family (LRKK) proteins are consists of an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40. Various genes and loci (a-synuclein/PARK1 and 4, parkin/PARK2, UCH-L1/PARK5, PINK1/PARK6, DJ-1/PARK7, LRRK2/PARK8, synphilin-1 and NR4A2) are associated to Parkinson’s Disease (PD). LRRK2 may play an important role as a therapeutic target for treatment of PD (5).
Synonyms	AURA17; DARDARIN; PARK8; RIPK7; ROCO2
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Parkinson's disease

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