TIGIT Mouse Monoclonal Antibody [Clone ID: [7E5]]

CAT#: TA355107

Mouse Monoclonal Anti-TIGIT Antibody [7E5]



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CNY 6,861.00


货期*
5周

规格
    • 100 ug

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Specifications

Product Data
Clone Name [7E5]
Applications FC, IF, IHC
Recommend Dilution IHC start at 2 - 5 ug/mL. IF start at 20 ug/mL.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen TIGIT antibody was raised against the extracellular domain of human TIGIT.
Formulation TIGIT Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification TIGIT Antibody is supplied as protein A purified IgG2b.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size Predicted: 26 kDa.
Gene Name T-cell immunoreceptor with Ig and ITIM domains
Background TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses .Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer .
Synonyms DKFZp667A205; FLJ39873; VSIG9; VSTM3; WUCAM
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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