BCMA (TNFRSF17) Rabbit Monoclonal Antibody [Clone ID: DM4]

Specifications

Product Data
Clone Name	DM4
Applications	FC, FN
Recommend Dilution	Flow Cyt  1/100; MMTumor cell killing
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	Recombinant human BCMA (Met1-Ala54) (TP723924) produced by using human HEK293 cells
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization. Preservative: 0.1% Procline 300
Reconstitution Method	Reconstitute with deionized water
Purification	Purified from cell culture supernatant by affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store at -20°C for 12 months (Avoid repeated freezing and thawing)
Predicted Protein Size	20kDa
Gene Name	tumor necrosis factor receptor superfamily member 17
Database Link	Entrez Gene 608 Human UniProt ID Q02223
Background	BiTE bispecific antibody is an Engineered fusion protein constructed from two single-chain variable fragments (scFvs) of different monoclonal antibodies. One of the scFvs will be constructed from an anti-CD3 monoclonal antibody, and the other scFv fragment which linked by a linker region will be made from an anti-Tumor cell specific monoclonal antibody.The B-cell maturation protein (BCMA or BCM) is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
Synonyms	BCM; BCMA; CD269
Reference Data

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