alpha Synuclein (SNCA) Mouse Monoclonal Antibody [Clone ID: KM51]

Specifications

Product Data
Clone Name	KM51
Applications	IHC
Recommend Dilution	1:20–1:40
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant protein corresponding to the majority of the full length alpha-synuclein molecule
Specificity	Alpha-synuclein, also known as the non-AB component of Alzheimer’s disease amyloid precursor protein (NCAP). Does not crossreact with beta-synuclein
Formulation	Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	synuclein alpha
Database Link	Entrez Gene 6622 Human UniProt ID P37840
Background	Alpha-synuclein is a protein of 140 amino acids and a member of the synuclein family. It shares 61% sequence homology with beta-synuclein and is highly conserved between vertebrate species. It does not possess a signal sequence suggesting that it is an intracellular protein. All synucleins have an unusual organization based around the eleven residue repeating motif and an alpha-helical secondary structure resembling those found in the lipid-binding domain of exchangeable apolipoproteins, including Apo E. This homology suggests a direct interaction of alpha-synuclein with membranes consistent with its affinity for synaptosomes. The function of alpha-synuclein may be to carry a target protein to the inner membrane of nerve terminals or to the outer surface of synaptic vesicles. Western Blot analyses of highly purified Lewy bodies from Lewy body dementia brain material has shown full-length, partially truncated and insoluble aggregates of alpha-synuclein. Alpha-synuclein may be implicated in the formation of Lewy bodies and the selective degeneration of neurons in sporadic Parkinson's disease and Lewy body dementia.
Synonyms	alpha-synuclein; MGC110988; NACP; OTTHUMP00000161559; OTTHUMP00000161561; PARK1; PARK4; PD1
Reference Data

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