CD13 (ANPEP) Mouse Monoclonal Antibody [Clone ID: 38C12]

Specifications

Product Data
Clone Name	38C12
Applications	IHC
Recommend Dilution	1:80
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant prokaryotic fusion protein corresponding to the C-terminal region of the extracellular domain
Specificity	Human CD13 antigen
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	alanyl aminopeptidase, membrane
Database Link	Entrez Gene 290 Human UniProt ID P15144
Background	CD13 antigen, also known as aminopeptidase N, is a member of type II integral membrane metalloproteases, which also includes the leukocyte antigens CD10, CD26, CD73 and BP-1. CD13 antigen is a receptor for the coronaviruses which cause respiratory disease in humans and several animal species. The antigen functions as a zinc-binding metalloprotease which plays a role in cell surface antigen presentation by trimming the N-terminal amino acids from MHC class II-bound peptides. CD13 antigen is reported to be expressed on granulocytes, monocytes and their precursors, most acute myeloid leukemias and a smaller proportion of acute lymphoid leukemias. Non-hematopoietic cells which express CD13 antigen include epithelial cells, renal proximal tubules, intestinal brush border, endothelial cells, fibroblasts, brain cells, bone marrow, osteoclasts and cells lining the bile canaliculi.
Synonyms	AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1; P150; PEPN
Reference Data

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