E Cadherin (CDH1) Mouse Monoclonal Antibody [Clone ID: 36B5]

Specifications

Product Data
Clone Name	36B5
Applications	IHC
Recommend Dilution	1:25
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant protein corresponding to the N-terminal external region of the E-Cadherin molecule
Specificity	Human E-Cadherin
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	cadherin 1
Database Link	Entrez Gene 999 Human UniProt ID P12830
Background	E-cadherin is a Ca2+-dependent, transmembrane cell adhesion molecule. It plays an important role in the growth, development and the intercellular adhesion of epithelial cells. Most tumors have an abnormal architecture and any subsequent loss of adhesiveness is thought to be an important step in the development of local invasion. E-cadherin may have a role in neoplastic progression, particularly as a suppressor of invasion. In prostate cancers, for example, the expression of E-cadherin is reported to be reduced or absent in comparison with its expression in normal prostate which is uniformly strong. Reduced expression or absence of E-cadherin in addition to alpha, beta and gamma-catenin in primary breast carcinomas has also been reported and these four proteins are associated with the development of metastases.
Synonyms	Arc-1; CD324; CDHE; E-Cadherin; ECAD; LCAM; UVO; uvomorulin
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.