p21 (CDKN1A) Mouse Monoclonal Antibody [Clone ID: 4D10]

Specifications

Product Data
Clone Name	4D10
Applications	IHC
Recommend Dilution	1:20 - 1:40
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant fusion protein corresponding to the full length WAF1 molecule
Specificity	Human WAF1 protein. (Also referred to as p21, Cip1 and sdi1 protein)
Formulation	Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	cyclin-dependent kinase inhibitor 1A
Database Link	Entrez Gene 1026 Human UniProt ID P38936
Background	The gene encoding WAF1, also termed p21, is transcriptionally regulated by the suppressor protein, p53. Overexpression of WAF1 is growth suppressive, possibly by inhibiting the activity of cyclin/CDK complexes. One consequence of WAF1 binding to cyclin/CDK complexes is the inhibition of Rb protein phosphorylation. Induction of WAF1 expression requires wild type p53 activity in cells undergoing p53 dependent G1 arrest or apoptosis. Mutation of the p53 gene is a common event in human cancer and results in the failure to produce WAF1. The effect of this may lead to uncontrolled cell proliferation.
Synonyms	CAP20; CDKN1; CIP1; MDA-6; MDA6; OTTHUMP00000016298; P21; p21CIP1; p21Cip1/Waf1; PIC1; SDI1; WAF1
Reference Data

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