FLT4 Mouse Monoclonal Antibody [Clone ID: KLT9]

Specifications

Product Data
Clone Name	KLT9
Applications	IHC
Recommend Dilution	1:50 - 1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A 227 amino acid region of the external domain of the human VEGFR-3 molecule
Specificity	Human vascular endothelial growth factor receptor-3 (VEGFR-3)
Formulation	Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	fms related tyrosine kinase 4
Database Link	Entrez Gene 2324 Human UniProt ID P35916
Background	VEGFR-3 (FLT4) is a receptor tyrosine kinase similar in structure to VEGFR-1 and VEGFR-2 but does not bind VEGF; however, the two known ligands have a high degree of homology to VEGF and are known as VEGF-C and VEGF-D. VEGFR-3 is reported to be found in many tissues including lung, intestine, brain and placenta (syncytiotrophoblasts). Throughout embryogenesis, VEGFR-3 mRNA is expressed in most endothelial cells, whilst being restricted to lymphatic vessels later in development. It appears to play an important role in the normal development of blood and lymphatic vessels. In tumors, expression has been reported in blood capillary endothelium and VEGFR-3 is thought to be involved in angiogenesis during tumor growth.
Synonyms	FLT41; LMPH1A; PCL; VEGFR-3; VEGFR3
Reference Data

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