KIR3DL1 Rabbit Polyclonal Antibody

CAT#: TA366277

KIR3DL1 rabbit polyclonal antibody

Size: 25 ul 100 ul



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CNY 1,999.00

CNY 3,280.00


货期*
2周

规格
    • 100 ul

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Specifications

Product Data
Applications IHC, WB
Recommend Dilution WB: 1000-5000
WB positive control: Human fetal liver tissue and Human liver tissue lysates
IHC: 50-300
Positive control: Human liver cancer
Predicted cell location: Cytoplasm
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Fusion protein of human KIR3DL1
Formulation pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C.
Predicted Protein Size 49 kDa
Gene Name killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1
Background Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3,KIR3DP1,KIR3DL4,KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM) while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus KIR proteins are thought to play an important role in regulation of the immune response.
Synonyms AMB11; CD158E; CD158E1; CD158e1/2; CD158e2; cl-2; cl-11; KIR; KIR3DS1; MGC119726; MGC119728; MGC126589; MGC126591; NK-receptor; NKAT-3; NKAT3; NKB1; NKB1B
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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