CNGA4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: Human cerebella tissue and Human cerebrum tissue lysates IHC: 20-100 Positive control: Human thyroid cancer Predicted cell location: Cell membrane
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide of human CNGA4
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Predicted Protein Size	66 kDa
Gene Name	cyclic nucleotide gated channel alpha 4
Database Link	Entrez Gene 1262 Human UniProt ID Q8IV77
Background	Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection.
Synonyms	CNCA2; CNG-4; CNG4; CNG5; CNGB2; MGC126168; MGC126169; OCNC2; OCNCb; OCNCBETA
Reference Data

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