EGLN1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB,1:500 - 1:2000
Reactivity	Human
Modifications	Unmodified
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide of human EGLN1/EGLN2
Formulation	Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20℃. Avoid freeze / thaw cycles.
Predicted Protein Size	36kDa/43kDa/46kDa/40kDa
Gene Name	egl-9 family hypoxia inducible factor 1
Database Link	Entrez Gene 54583 Human UniProt ID Q9GZT9
Background	The proteins encoded by EGLN1/EGLN2 gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex.
Synonyms	C1orf12; DKFZp761F179; ECYT3; HIF-PH2; HIFPH2; HPH-2; HPH2; PHD2; SM-20; SM20; ZMYND6
Reference Data

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