BNIP3 Rabbit Monoclonal Antibody [Clone ID: R09-1G8]

Specifications

Product Data
Clone Name	R09-1G8
Applications	IF, WB
Recommend Dilution	WB: 1/1000 ICC/IF: 1/50
Reactivity	Human, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human BNIP3
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 28 kDa; Observed MW: 28 kDa
Gene Name	BCL2/adenovirus E1B 19kDa interacting protein 3
Database Link	Entrez Gene 664 Human UniProt ID Q12983
Background	Swiss-Prot Acc.Q12983.Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
Synonyms	NIP3
Reference Data

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