Caspase 3 (CASP3) Rabbit Monoclonal Antibody [Clone ID: R04-5C8]

Specifications

Product Data
Clone Name	R04-5C8
Applications	WB
Recommend Dilution	WB: 1/1000
Reactivity	Mouse, Human, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of mouse Caspase-3 (Cleaved)
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 32 kDa; Observed MW: 32,17 kDa
Gene Name	caspase 3
Database Link	Entrez Gene 836 Human UniProt ID P42574
Background	Swiss-Prot Acc.P70677.Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage . Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.
Synonyms	apopain; CASP-3; CPP-32; CPP32; CPP32B; procaspase3; SCA-1; Yama
Reference Data

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