CAF1 (CHAF1A) Rabbit Monoclonal Antibody [Clone ID: R06-3A5]

Specifications

Product Data
Clone Name	R06-3A5
Applications	IF, IHC, IP, WB
Recommend Dilution	WB: 1/1000 IHC: 1/50 ICC/IF: 1/200-1/1000 IP: 1/20
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human p150 CAF1
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 107 kDa; Observed MW: 150 kDa
Gene Name	chromatin assembly factor 1 subunit A
Database Link	Entrez Gene 10036 Human UniProt ID Q13111
Background	Swiss-Prot Acc.Q13111.Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci .
Synonyms	CAF; CAF-1; CAF-Ip150; CAF1; CAF1B; CAF1P150; hp150; MGC71229; P150
Reference Data

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