Nogo B receptor (NUS1) Rabbit Monoclonal Antibody [Clone ID: R01-3K8]
CAT#: TA384884
Nogo B Receptor Rabbit monoclonal Antibody
Size: 20 ul
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Specifications
Product Data | |
Clone Name | R01-3K8 |
Applications | WB |
Recommend Dilution | WB: 1/1000 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Monoclonal |
Immunogen | A synthetic peptide of human Nogo B receptor |
Formulation | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
Concentration | lot specific |
Purification | Affinity Purified |
Conjugation | Unconjugated |
Storage Condition | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Predicted Protein Size | Calculated MW: 33 kDa; Observed MW: 33 kDa |
Gene Name | NUS1 dehydrodolichyl diphosphate synthase subunit |
Database Link | |
Background | Swiss-Prot Acc.Q96E22.With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:21572394, PubMed:25066056, PubMed:28842490). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (PubMed:16835300). |
Synonyms | C6orf68; MGC7199; MGC117249; MGC:7199; NgBR |
Reference Data |
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