POLR2E Rabbit Monoclonal Antibody [Clone ID: R05-8J5]

Specifications

Product Data
Clone Name	R05-8J5
Applications	IHC, WB
Recommend Dilution	WB: 1/2000 IHC: 1/20
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human POLR2E
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 25 kDa; Observed MW: 25 kDa
Gene Name	polymerase (RNA) II subunit E
Database Link	Entrez Gene 5434 Human UniProt ID P19388
Background	Swiss-Prot Acc.P19388.DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process .
Synonyms	hRPB25; hsRPB5; RPABC1; RPB5; XAP4
Reference Data

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