CD30 (TNFRSF8) Rabbit Monoclonal Antibody [Clone ID: Ki-4]

Specifications

Product Data
Clone Name	Ki-4
Applications	ELISA, FC, IF, IHC
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	Human CD30.
Specificity	The antibody binds to CD30. The antibody binds specifically to CD30, a cell membrane protein which belongs to the tumour necrosis factor receptor family. Incubation of CD30 positive L540 cells with Ki-4 antibody completely inhibits release of soluble CD30 (in contrast to Ki-3, Ab00474). CD30 is expressed on activated lymphocytes, and binding by its ligands TRAF2 and TRAF5 results in the activation of NF-kappaB, thereby regulating gene expression. CD30 is also associated with Hodgkin Lymphoma, and its expression acts as a tumour marker. Targeting the CD30 antigen with specific monoclonal antibodies is a possible therapy for Hodgkin's lymphoma.
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Gene Name	tumor necrosis factor receptor superfamily member 8
Database Link	Entrez Gene 943 Human UniProt ID P28908
Synonyms	CD30; D1S166E; KI-1
Note	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Reference Data

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