Eng Rabbit Monoclonal Antibody [Clone ID: MJ7/18]

Specifications

Product Data
Clone Name	MJ7/18
Applications	FC, IHC, IP, WB
Reactivity	Mouse
Host	Rabbit
Clonality	Monoclonal
Immunogen	MJ7/18 was prepared by immunizing rats with inflamed mouse skin tissue. The antibody was selected immunohistologically for reactivity with endothelial cells.
Specificity	MJ7/18 binds specifically to mouse CD105. CD105 is a homodimer expressed by vascular endothelial cells. CD105 functions in adhesion and embryonic angiogenesis. CD105 is a major homodimeric glycoprotein of vascular endothelium involved in cell ahesion through integrin/RGD binding and the regulation of angiogenesis. Also acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. CD105 is also required for GDF2/BMP9 signaling through SMAD1 in endothelial cells. MJ7/18 can be used for FC, WB, IP and IHC (Baluk P, et al. 2003. Am. J. Pathol. 163:1801).
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Gene Name	endoglin
Database Link	Entrez Gene 13805 Mouse UniProt ID Q63961
Synonyms	CD105; END; endoglin; FLJ41744; HHT1; ORW; ORW1
Note	This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Reference Data

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