TNF alpha (TNF) Mouse Monoclonal Antibody [Clone ID: D2E7 (Adalimumab)]

Specifications

Product Data
Clone Name	D2E7 (Adalimumab)
Applications	Bl, ELISA, IF, IHC
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	This antibody was generated by affinity maturation from the 2SD4 scFv, which in turn was selected on human TNF alpha by guided phage-display technology, using the murine anti-hTNF alpha antibody Mab32 as a template (c.f. also US Patent 6090382).
Specificity	Binds to soluble TNF-alpha, but not to lymphotoxin (TNF beta). Adalimumab binds specifically to TNF and neutralizes the biological function of TNF by blocking its interaction with the p55 and p75 cell surface TNF receptors. Adalimumab, unlike Infliximab (Ab00146), was shown to be cross-reactive with mouse TNF alpha (Arnoult 2017, PMID: 28584008).
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Gene Name	tumor necrosis factor
Database Link	Entrez Gene 7124 Human UniProt ID P01375
Synonyms	Cachectin; DIF; TNF-a; TNF-alpha; TNFA; TNFSF2
Note	This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Reference Data

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