Tnfsf11 Rabbit Monoclonal Antibody [Clone ID: IK22-5]

Specifications

Product Data
Clone Name	IK22-5
Applications	FC, IHC, Neutralize
Reactivity	Mouse
Host	Rabbit
Clonality	Monoclonal
Immunogen	Thus antibody was raised by immunising an SD rat with murine RANKL-transfected baby hamster kidney cells.
Specificity	This antibody is specific for murine RANKL. This antibody has been used in immunohistochemical analysis of frozen Peyer's patch tissue sections (Kobayashi et al, 2013). It has also been used in flow cytometric analysis of RANKL cell surface expression by Th1 and Th17 cells (Nakae et al, 2007), RANKL-transfected human embryonic kidney cells (Miyahira et al, 2003) and murine T hybridoma 2B4.11 cells (Fionda et al, 2007). Additionally, this RANKL-neutralising antibody has been used to assess the effects of RANKL inhibition on myoepithelial cell proliferation in mammary organoid culture (Haslam et al, 2008). Treatment of collagen-induced arthritis (CIA) mice with this antibody has been shown to reduce bone loss at the site of inflammation (Kamijo et al, 2006), while administration to C57BL/6J mice induced transient tibia and skull bone growth arrest and irreversible blockage of tooth eruption (Lezot et al, 2015).
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Gene Name	tumor necrosis factor (ligand) superfamily, member 11
Database Link	Entrez Gene 21943 Mouse UniProt ID O35235
Synonyms	CD254; hRANKL2; ODF; OPGL; OPTB2; OTTHUMP00000178585; RANKL; sOdf; TRANCE
Note	This chimeric rabbit antibody was made using the variable domain sequences of the original rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Reference Data

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