CD71 (TFRC) Mouse Monoclonal Antibody [Clone ID: DF1513]

Specifications

Product Data
Clone Name	DF1513
Applications	IHC, WB
Recommend Dilution	WB: 1:1000
Host	Mouse
Clonality	Monoclonal
Immunogen	Preparation of KG1 cells
Specificity	Specific for endogenous levels of the ~98 kDa CD71 protein.
Formulation	PBS
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
Predicted Protein Size	98
Gene Name	transferrin receptor
Database Link	UniProt ID P02786
Background	CD71, also known as the transferrin receptor (TfR1), is a transmembrane glycoprotein whose primary function is to mediate cellular uptake of iron from a plasma glycoprotein, transferrin. CD71 is a widely used marker for cell activation or proliferation of lymphocytes as transferrin receptor expression is undetectable in resting T and B lymphocytes, but increases significantly upon lymphocyte antigen activation (Galbraith, R.M., et al 1981). Rapidly proliferating cells and energy-requiring cells, like cancer cells, osteoclasts (Roodman, G.D., 2009), and activated lymphocytes (Wieland, E., et al, 2016) express high levels of CD71 due to increased iron demand. TfR1 is seen as an efficient drug delivery system for cancer patients as it can mediate extracellular transferrin conjugated molecules for treatment (Luria-Perez, R., et al, 2016).
Synonyms	CD71; p90; T9; TfR; TfR1; TR; Trfr
Note	Protein G purified culture supernatant.
Reference Data

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