Anti-BAFF-R antibody(DM143), Rabbit mAb

Specifications

Product Data
Clone Name	DM143
Applications	ELISA, FC
Recommend Dilution	ELISA 1:5000-10000 Flow Cyt 1:100
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Formulation	1XPBS
Concentration	Lot specific
Purification	Purified from cell culture supernatant by affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Background	B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.
Synonyms	BAFFR,TNFRSF13C,BAFF-R,BROMIX,CD268,CVID4,prolixin
Reference Data

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