CD6 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:1000~1:2000
Reactivity	Rat, Mouse, Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human CD6.
Specificity	CD6 polyclonal antibody detects endogenous levels of CD6 protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 95 kDa
Gene Name	CD6 molecule
Database Link	Entrez Gene 923 Human UniProt ID P30203
Background	Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166.Contributes to signaling cascades triggered by activation of the TCR/CD3 complex.Functions as costimulatory molecule; promotes T-cell activation and proliferation.Contributes to the formation and maturation of the immunological synapse.Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria.LPS binding leads to the activation of signaling cascades and down-stream MAP kinases.Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS.
Synonyms	CD6; Soluble CD6; T-cell differentiation antigen CD6; T12; TP120
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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