NR2F2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1:1000~1:2000 IHC: 1:50~1:200
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to Human COUP-TF II.
Specificity	COUP-TF II polyclonal antibody detects endogenous levels of COUP-TF II protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 47 kDa
Gene Name	nuclear receptor subfamily 2 group F member 2
Database Link	Entrez Gene 7026 Human UniProt ID P24468
Background	Chicken ovalbumin upstream promoter transcription factor (COUP-TF) belongs to the NR2 subfamily of the nuclear hormone receptor family. COUP-TFI and COUP-TFII are two of the well-characterized members in the NR2 subfamily. These two members are highly conserved in their two zinc-finger DNA binding domains (DBD) and the ligand binding domain (LBD), and function as repressors or activators of downstream target genes to regulate different biological processes . COUP-TFI and II bind to 5'-AGGTCA-3' motif palindromes, either directly or indirectly, through heterodimer formation with other proteins (e.g. RXRs) to regulate downstream target gene expression. COUP-TFI is involved in neuronal development, tissue patterning, and differentiation . COUP-TFII has been shown to be involved in angiogenesis, glucose homeostasis, and mesenchymal cell commitment.
Synonyms	Apolipoprotein A-I regulatory protein 1; ARP-1; ARP1; COUP-TF2; COUP-TF II; COUP transcription factor 2; COUP transcription factor II; NR2F2; Nuclear receptor subfamily 2 group F member 2; TFCOUP2
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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