H3FA (HIST1H3A) Rabbit Polyclonal Antibody

CAT#: TA392517

Histone H3 (Phospho-S28) polyclonal antibody

Size: 25 ul 100 ul



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CNY 1,999.00

CNY 3,350.00


货期*
2周

规格
    • 100 ul

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Specifications

Product Data
Applications IF, WB
Recommend Dilution WB: 1:1000~1:2000 IF: 1:50~1:200
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic phosphopeptide derived from human Histone H3 around the phosphorylation site of Serine 28.
Specificity Histone H3 (Phospho-S28) polyclonal antibody detects endogenous levels of Histone H3 protein only when phosphorylated at Ser28.
Formulation Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Concentration 1mg/ml
Conjugation Unconjugated
Storage Condition Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size ~ 19 kDa
Gene Name histone cluster 1, H3a
Background Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin. The amino-terminal tails of core histones undergo various posttranslational modifications, including acetylation, phosphorylation, methylation, and ubiquitination. These modifications occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression. In most species, histone H2B is primarily acetylated at Lys5, 12, 15, and 20. Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10, Ser28, and Thr11 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis. Phosphorylation at Thr3 of histone H3 is highly conserved among many species and is catalyzed by the kinase haspin. Immunostaining with phospho-specific antibodies in mammalian cells reveals mitotic phosphorylation at Thr3 of H3 in prophase and its dephosphorylation during anaphase.
Synonyms H3/a; H3/b; H3/c; H3/d; H3/f; H3/h; H3/i; H3/j; H3/k; H3/l; H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12; H3FA; H3FB; H3FC HIST1H3C; H3FD; H3FF; H3FH; H3FI; H3FJ; H3FK; H3FL; HIST1H3A; HIST1H3B; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; Histone H3.1
Note For research use only, not for use in diagnostic procedure.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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