Nurr1 (NR4A2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:2000~1:5000 IHC: 1:50~1:200
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to Human NURR1.
Specificity	NURR1 polyclonal antibody detects endogenous levels of NURR1 protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 75 kDa
Gene Name	nuclear receptor subfamily 4 group A member 2
Database Link	Entrez Gene 4929 Human UniProt ID P43354
Background	Nurr1 (Nur-related factor 1) and Nur77 (also designated NGFI-B) encodeorphan nuclear receptors which may comprise an additional subfamily withinthe nuclear receptor superfamily. The rat and human homologs of mouse Nurr1are designated RNR1 and NOT, respectively. Both Nurr1 and Nur77 are growthfactor inducible, immediate early response genes. Induction of both Nurr1 andNur77 is seen after membrane depolarization while only Nur77 induction isseen with NGF stimulation. JunD acts as a mediator for Nur77. An increase in Nurr77 expression is seen in activated T cells during G0 to G1 transition andthroughout the G1 phase. In addition to its function as an immediate earlygene, Nur77 may play a role in TCR-mediated apoptosis. Cyclosporin A, apotent immuno-suppressant, has been shown to inhibit the ability of Nur77to bind DNA. A dominant negative form of Nur77 can protect T cell hybridomas from activation-induced apoptosis. However, the absolute requirementof Nur77 for TCR-mediated apoptosis is still under debate.
Synonyms	Immediate-early response protein NOT; NOT; NR4A2; Nuclear receptor subfamily 4 group A member 2; NURR1; Orphan nuclear receptor NURR1; TINUR; Transcriptionally-inducible nuclear receptor
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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