Beclin 1 (BECN1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1:1000~1:2000 IF: 1:50~1:200
Reactivity	Human, Rat, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to Human Beclin 1.
Specificity	Beclin 1(R238) polyclonal antibody detects endogenous levels of Beclin 1 protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 51 kDa
Gene Name	beclin 1
Database Link	Entrez Gene 8678 Human UniProt ID Q14457
Background	BECN1 (beclin 1) is a coiled-coil protein that has been implicated as an inhibitor of tumorigenesis. BECN1, which associates with Bcl-2, plays a significant role in autophagy. Autophagy is the degradation of cellular proteins in the lysosomes, and when this pathway is suppressed, cell growth is deregulated. Autophagy is controlled by the same signal transduction pathway that induces the phosphorylation of the ribosomal protein S6, and both are mediated via amino acids. BECN1 expression in various carcinoma cell lines, such as MCF7, is low, whereas it is ubiquitously expressed in normal breast tissue. In transfected MCF7 cells, BECN1 complements autophagocytosis and, subsequently, inhibits cellular proliferation. Additionally, BECN1 shares structural similarity to the yeast autophagy gene product, APG6, and was one of the first mammalian proteins discovered to mediate autophagy.
Synonyms	APG6; ATG 6; ATG6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein beclin; Beclin-1; Beclin1; Beclin 1 (coiled coil moesin like BCL2 interacting protein); Beclin 1 autophagy related; BECN 1; BECN1; Coiled-coil myosin-like BCL2-interacting protein; Coiled coil myosin like BCL2 interacting protein; GT197; Protein GT197 antibod
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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