AKAP10 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000 IHC: 1:50~1:200
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 1-50 of Human AKAP 10.
Specificity	AKAP 10 (R27) polyclonal antibody detects endogenous levels of AKAP 10 protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 74 kDa
Gene Name	A-kinase anchoring protein 10
Database Link	Entrez Gene 11216 Human UniProt ID O43572
Background	AKAP 10 (A kinase anchor protein 10), also known as PRKA10 or D-AKAP2 (dual-specific A kinase-anchoring protein 2), is a 662 amino acid mitochondrial membrane protein that belongs to the AKAP family. AKAP 10 is a dual specificity protein that binds to both type I and type II regulatory subunits of PKA and anchors them to the plasma membrane or the mitochondria. When anchored to the mitochondria, PKA can phosphorylate and, thus, inactivate the proapoptotic protein Bad. This suggests that AKAP 10 indirectly regulates Bad-induced apoptosis by mediating the mitochondrial attachment of PKA. Additionally, AKAP 10 may facilitate G-protein coupled signal transduction and could act as an adaptor in the assembly of multiprotein complexes.
Synonyms	A-kinase anchor protein 10, mitochondrial; AKAP-10; AKAP10; D-AKAP-2; Dual specificity A kinase-anchoring protein 2; PRKA10; Protein kinase A-anchoring protein 10
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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