PHF1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500~1:1000 IHC: 1:50~1:200
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 361-410 of Human PHF1.
Specificity	PHF1 (K381) polyclonal antibody detects endogenous levels of PHF1 protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 62 kDa
Gene Name	PHD finger protein 1
Database Link	Entrez Gene 5252 Human UniProt ID O43189
Background	PHF1 (PHD protein finger 1), also known as polycomb-like protein 1 or hPCI1, is a 567 amino acid member of the PHD finger protein family. Members of the PHD finger protein family function as transcriptional regulators that affect gene expression by modulating chromatin structure. With a subcellular localization to the nucleus, PHF1 is widely expressed in tissues, with high expression in pancreas, heart and skeletal muscle and low expression in liver, lung, kidney, brain and placenta. PHF1 contains 2 PHD-type zinc finger domains, which may contribute to the transcriptional activity of PHF1. PHF1 is thought to interact with ENX-1, a component of PRC2 (polycomb repressive complex 2), increasing the gene silencing activity of PRC2. PHF1 exists as two isoforms produced by alternative splicing.
Synonyms	hPCl1; hPHF1; PCL1; PHD finger protein 1; PHF1; Polycomb-like protein 1; Protein PHF1
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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