CDX2 Rabbit Monoclonal Antibody [Clone ID: 12B6]

Specifications

Product Data
Clone Name	12B6
Applications	ELISA, IHC, WB
Reactivity	Human
Modifications	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2b format for improved compatibility with existing reagents assays and techniques.
Host	Rabbit
Clonality	Monoclonal
Immunogen	The original antibody was generated by immunizing a mouse with the CDX2-KLH protein.
Specificity	The antibody recognises human CDX2. The CDX2 protein is a homeobox transcription factor expressed in the nuclei of intestinal epithelial cells, playing an essential role in the development and function of the digestive system. The antibody was used for immunohistochemistry on stomach adenocarcinoma, showing accurate staining location, clear staining, no non-specific staining, and clean background. Further, immunohistochemistry staining on stomach adenocarcinoma from 12B6 antibody and the commercial antibody, rabbit mono-ERP2764Y, were compared. Results showed the staining intensity of 12B6 antibody was significantly higher than those of ERP2764Y, showing 12B6 antibody is more sensitive. Moreover, the antibody and the commercial antibody TA347 were used for immunohistochemistry on appendix tissue. Results showed that the antibody (12B6) and the commercially available antibody (TA347) were simultaneously detected on the normal tissue chip, and the negative and positive detection results were consistent, indicating that the specificity of the antibody in normal tissue was equivalent to that of the commercially available antibody. The antibody detected human CDX2 by western blot analysis (CN113265000).
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Database Link	UniProt ID Q99626
Synonyms	Caudal-type homeobox protein 2; CDX-3; Homeobox protein CDX-2; rabbit mono-ERP2764Y; TA347
Reference Data

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