Phospho-POLR2A Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ChIP, IP, WB
Recommend Dilution	WB,1:1000 - 1:5000 IP,1:2000 - 1:6000 ChIP,1:50 - 1:200
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A phospho specific peptide corresponding to residues surrounding S2/S5 of human POLR2A.
Formulation	Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20℃. Avoid freeze / thaw cycles.
Predicted Protein Size	217kDa - Observed MW: 270kDa
Gene Name	polymerase (RNA) II subunit A
Database Link	Entrez Gene 5430 Human UniProt ID P24928
Background	This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
Synonyms	hRPB220; hsRPB1; NEDHIB; POLR2; POLRA; RPB1; RPBh1; RpIILS; RPO2; RPOL2
Reference Data

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