Noggin (NOG) Mouse Monoclonal Antibody [Clone ID: OTI1C1]

CAT#: TA500116S

Anti-Noggin (Noggin) mouse monoclonal antibody, clone OTI1C1 (formerly 1C1)

Size: 30 ul 100 ul



  View other "OTI1C1" antibodies (4)

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CNY 800.00


货期*
现货

规格
    • 30 ul

经常一起买 (2)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

CNY 300.00
CNY 1,430.00


Transient overexpression lysate of noggin (NOG)
    • 100 ug

CNY 3,080.00

Specifications

Product Data
Clone Name OTI1C1
Applications IF, IHC, WB
Recommend Dilution WB: 1:40000, IHC 1:50, IF (1:100)
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Immunogen Recombinant protein expressed in E.coli corresponding to amino acids 28-232 of human noggin
Formulation PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 23.7 kDa
Gene Name noggin
Background Noggin is a secreted polypeptide which binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, it may have a principal role in creating morphogenic gradients. Noggin appears to have pleiotropic effect, both early in development as well as in later stages. The results of the mouse knockout of the ortholog suggest that noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse
Synonyms SYM1; SYNS1; SYNS1A
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways TGF-beta signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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