Protein Kinase A regulatory subunit I alpha (PRKAR1A) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI6C7]
CAT#: TA500641BM
PRKAR1A mouse monoclonal antibody, clone 6C7, HRP conjugated
Conjugation: Unconjugated Biotin
View other "OTI6C7" antibodies (4)
Need it in bulk or conjugated?
Get a free quote
CNY 3,990.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
CNY 3,080.00
Specifications
Product Data | |
Clone Name | OTI6C7 |
Applications | IF, IHC, WB |
Recommend Dilution | WB 1:2000, IHC 1:50, IF 1:100 |
Reactivity | Human, Mouse, Rat |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Full-length protein expressed in 293T cell transfected with human PRKAR1A expression vector |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol. |
Concentration | 0.5 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | HRP |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 43.0 kDa |
Gene Name | protein kinase cAMP-dependent type I regulatory subunit alpha |
Database Link | |
Background | cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed. |
Synonyms | ACRDYS1; ADOHR; CAR; CNC; CNC1; PKR1; PPNAD1; PRKAR1; TSE1 |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
Protein Pathways | Apoptosis, Insulin signaling pathway |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF500641 | Carrier-free (BSA/glycerol-free) PRKAR1A mouse monoclonal antibody, clone OTI6C7 (formerly 6C7) |
CNY 3,999.00 |
|
TA500641 | Anti-PRKAR1A (PKA regulatory subunit I alpha) mouse monoclonal antibody, clone OTI6C7 (formerly 6C7) |
CNY 1,999.00 |
|
TA500641AM | PRKAR1A mouse monoclonal antibody, clone 6C7, Biotinylated |
CNY 3,990.00 |
|
TA500641S | Anti-PRKAR1A (PKA regulatory subunit I alpha) mouse monoclonal antibody, clone OTI6C7 (formerly 6C7) |
CNY 800.00 |
其它Protein Kinase A regulatory subunit I alpha产品