FMRP (FMR1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1C6]

Specifications

Product Data
Clone Name	OTI1C6
Applications	FC, IF, IHC, WB
Recommend Dilution	WB 1:500~2000, IHC 1:150, IF 1:100, FLOW 1:100
Reactivity	Human, Dog, Rat, Monkey, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 36-279 of human FMR1(NP_002015) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	71 kDa
Gene Name	FMRP translational regulator 1
Database Link	NP_002015 Entrez Gene 14265 MouseEntrez Gene 24948 RatEntrez Gene 481070 DogEntrez Gene 700138 MonkeyEntrez Gene 2332 Human UniProt ID Q06787
Background	The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene. [provided by RefSeq, May 2010]
Synonyms	FMRP; FRAXA; POF; POF1; POFX
Reference Data
Protein Families	Druggable Genome

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