BCAT1 Mouse Monoclonal Antibody [Clone ID: OTI3F5]
CAT#: TA504360
BCAT1 mouse monoclonal antibody, clone OTI3F5 (formerly 3F5)
Size: 30 ul
Formulation: Carrier-Free
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Cited in 8 publications. |
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Specifications
Product Data | |
Clone Name | OTI3F5 |
Applications | IHC, WB |
Recommend Dilution | WB 1:500~2000, IHC 1:150 |
Reactivity | Human, Dog, Mouse |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Full length human recombinant protein of human BCAT1(NP_005495) produced in HEK293T cell. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | Lot dependent |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 42.8 kDa |
Gene Name | branched chain amino acid transaminase 1 |
Database Link | |
Background | This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described. [provided by RefSeq] |
Synonyms | BCATC; BCT1; ECA39; MECA39; PNAS121; PP18 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Metabolic pathways, Pantothenate and CoA biosynthesis, Valine, leucine and isoleucine biosynthesis, Valine, leucine and isoleucine degradation |
Citations (8)
The use of this Antibodies has been cited in the following citations: |
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METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism.
,null,
Cell stem cell
,PubMed ID 36608679
[BCAT1]
|
Metabolon formation regulates branched-chain amino acid oxidation and homeostasis.
,null,
Nature metabolism
,PubMed ID 36443523
[BCAT1]
|
A Set of Cell Lines Derived from a Genetic Murine Glioblastoma Model Recapitulates Molecular and Morphological Characteristics of Human Tumors
,Costa, B;Fletcher, MNC;Boskovic, P;Ivanova, EL;Eisemann, T;Lohr, S;Bunse, L;Löwer, M;Burchard, S;Korshunov, A;Coltella, N;Cusimano, M;Naldini, L;Liu, HK;Platten, M;Radlwimmer, B;Angel, P;Peterziel, H;,
Cancers
,PubMed ID 33435218
[BCAT1]
|
A novel neural stem cell-derived immunocompetent mouse model of glioblastoma for preclinical studies
,Costa, B;Fletcher, MNC;Boskovic, P;Ivanova, EL;,
bioRxiv
[BCAT1]
|
BCAA catabolism in brown fat controls energy homeostasis through SLC25A44
,Yoneshiro, T;Wang, Q;Tajima, K;Matsushita, M;Maki, H;Igarashi, K;Dai, Z;White, PJ;McGarrah, RW;Ilkayeva, OR;Deleye, Y;Oguri, Y;Kuroda, M;Ikeda, K;Li, H;Ueno, A;Ohishi, M;Ishikawa, T;Kim, K;Chen, Y;Sponton, CH;Pradhan, RN;Majd, H;Greiner, VJ;Yoneshiro, M;Brown, Z;Chondronikola, M;Takahashi, H;Goto, T;Kawada, T;Sidossis, L;Szoka, FC;McManus, MT;Saito, M;Soga, T;Kajimura, S;,
Nature
,PubMed ID 31435015
[BCAT1]
|
BCAT1 is a New MR Imaging-related Biomarker for Prognosis Prediction in IDH1-wildtype Glioblastoma Patients
,Cho, HR;Jeon, H;Park, CK;Park, SH;Kang, KM;Choi, SH;,
Sci Rep
,PubMed ID 29255149
[BCAT1]
|
Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia
,Hattori, A;Tsunoda, M;Konuma, T;Kobayashi, M;Nagy, T;Glushka, J;Tayyari, F;McSkimming, D;Kannan, N;Tojo, A;Edison, AS;Ito, T;,
Nature
,PubMed ID 28514443
[Bcat1]
|
Temozolomide in combination with metformin act synergistically to inhibit proliferation and expansion of glioma stem-like cells
,null,
Oncology Letters
,PubMed ID 27073554
[BCAT1]
|
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF504360 | Carrier-free (BSA/glycerol-free) BCAT1 mouse monoclonal antibody, clone OTI3F5 (formerly 3F5) |
CNY 3,999.00 |
|
TA504360AM | BCAT1 mouse monoclonal antibody, clone OTI3F5 (formerly 3F5), Biotinylated |
CNY 3,990.00 |
|
TA504360BM | BCAT1 mouse monoclonal antibody, clone OTI3F5 (formerly 3F5), HRP conjugated |
CNY 3,990.00 |
|
TA504360S | BCAT1 mouse monoclonal antibody, clone OTI3F5 (formerly 3F5) |
CNY 800.00 |