PSMF1 Mouse Monoclonal Antibody [Clone ID: OTI2F9]

Specifications

Product Data
Clone Name	OTI2F9
Applications	IF, WB
Recommend Dilution	WB 1:2000, IF 1:100
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human PSMF1(NP_848693) produced in HEK293T cell.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	29.6 kDa
Gene Name	proteasome inhibitor subunit 1
Database Link	NP_848693 Entrez Gene 689852 RatEntrez Gene 9491 Human UniProt ID Q92530
Background	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Synonyms	PI31
Reference Data
Protein Pathways	Proteasome

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