GCLC Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI1A3]

Specifications

Product Data
Clone Name	OTI1A3
Applications	IHC, WB
Recommend Dilution	WB 1:200~1000, IHC 1:150
Reactivity	Human, Rat, Monkey, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human GCLC(NP_001489) produced in HEK293T cell.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	HRP
Storage Condition	Store at -20°C as received.
Predicted Protein Size	72.6 kDa
Gene Name	glutamate-cysteine ligase catalytic subunit
Database Link	NP_001489 Entrez Gene 14629 MouseEntrez Gene 25283 RatEntrez Gene 710508 MonkeyEntrez Gene 2729 Human UniProt ID P48506
Background	Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction. [provided by RefSeq, Oct
Synonyms	GCL; GCS; GLCL; GLCLC
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Glutathione metabolism, Metabolic pathways

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