CA12 Biotinylated Mouse Monoclonal Detection Antibody (Biotin conjugated) [Clone ID: OTI3F1]

Specifications

Product Data
Clone Name	OTI3F1
Applications	ELISA
Recommend Dilution	ELISA 1:1000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human CA12(NP_001209) produced in HEK293T cell.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Predicted Protein Size	39.5 kDa
Gene Name	carbonic anhydrase 12
Database Link	NP_001209 Entrez Gene 771 Human UniProt ID O43570
Background	Carbonic anhydrase 12 (CA12) is an enzyme that in humans is encoded by the CA12 gene. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Loss of function mutations in the CA12 gene result in defects in fluids and carbonate secretions, which is involved in cystic fibrosis-like syndrome with normal cystic fibrosis transmembrane conductance regulator (CFTR) protein levels, pancreatitis, Sjögren's syndrome and Xerostomia or dry mouth syndrome. It has been shown that CA12 expression is associated with a better prognosis in an unselected series of invasive breast carcinoma patients. Moreover, serum CA12 levels have been found significantly higher in lung cancer patients than in healthy controls, supporting that CA12 may be a promising diagnostic marker for lung cancer.
Synonyms	CA-XII; CAXII; HsT18816; T18816
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Nitrogen metabolism

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