PGP9.5 (UCHL1) Biotinylated Rabbit Monoclonal Detection Antibody [Clone ID: OTIR2F11]

Specifications

Product Data
Clone Name	OTIR2F11
Applications	ELISA
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within human UCHL1 (NP_004172). The exact sequence is proprietary.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Predicted Protein Size	24.8 kDa
Gene Name	ubiquitin C-terminal hydrolase L1
Database Link	NP_004172 Entrez Gene 7345 Human UniProt ID P09936
Background	Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is abundantly present in all neurons, expressed specifically in neurons and testis/ovary. UCHL1 has been proposed as a candidate biomarker for brain injury. Baseline levels of the biomarker UCHL1 measured in cerebral spinal fluid (CSF) are predictive of long-term multiple sclerosis (MS) progression. Recent studies have demonstrated that UCHL1 could be a potential biomarker for multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, aggressive multiple myeloma and for discriminating the Parkinson’s disease.
Synonyms	HEL-117; HEL-S-53; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; SPG79; Uch-L1
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Parkinson's disease

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