Calcitonin (CALCA) Biotinylated Mouse Monoclonal Detection Antibody [Clone ID: OTI1E7]

Specifications

Product Data
Clone Name	OTI1E7
Applications	ELISA
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human CLACA. The exact sequence is proprietary.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Predicted Protein Size	15.5 kDa
Gene Name	calcitonin related polypeptide alpha
Database Link	NP_001732 Entrez Gene 796 Human UniProt ID P01258
Background	Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin. It is produced by parafollicular cells (C cells) of the thyroid and by the neuroendocrine cells of the lung and the intestine. Under normal conditions procalcitonin is cleaved by endopeptidase to form mature hormone calcitonin. The level of procalcitonin rises during bacterial infection. It is often classed as an acute phase reactant and has become a marker of bacterial infection. Measurement of PCT can be used as a marker of severe sepsis caused by bacteria, and could help diagnose infectious complications of inflammatory bowel disease. In acute meningitis, serum PCT is useful as a biomarker for sepsis. PCT is often high in patients with chronic kidney disease and end-stage renal disease. In patients with atherosclerosis or coronary heart disease PCT is also valuable as a prognostic marker as its levels correlate with the severity of the illness. In addition, procalcitonin is reliable to monitor recurrence of medullary thyroid carcinoma.
Synonyms	CALC1; CGRP; CGRP-alpha; CGRP-I; CGRP1; CT; KC; PCT
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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