Methionine Aminopeptidase 2 (METAP2) Mouse Monoclonal Antibody [Clone ID: OTI1F6]

Specifications

Product Data
Clone Name	OTI1F6
Applications	FC, IF, IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:150, IF 1:100, FLOW 1:100
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 2-212 of human METAP2 (NP_006829) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	52.7 kDa
Gene Name	methionyl aminopeptidase 2
Database Link	NP_006829 Entrez Gene 56307 MouseEntrez Gene 64370 RatEntrez Gene 10988 Human UniProt ID P50579
Background	This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. [provided by RefSeq]
Synonyms	MAP2; MNPEP; p67eIF2
Reference Data
Protein Families	Druggable Genome, Protease

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